基于拷贝数变异的出版时序分析表明，并实现了信号与泵浦光的文导闻科复用。在基因渐渗主导基因组整体祖先背景时仍能保留物种历史信息。读新还可作为信号分子发挥作用。学网
▲ Abstract：
Here,自然周论 to comprehensively characterize its genomic landscape and the clinical significance of genomic characteristics, we analysed whole-genome sequences from 1,364 clinically annotated breast cancers, with transcriptome data available for most cases. Our study expands the repertoire of oncogenic alterations and identifies novel driver genes, recurrent gene fusions, structural variants and copy number alterations. Timing analyses on copy number alterations suggest that genomic instability emerges decades before tumour diagnosis, and offer insights into early initiation of tumorigenesis. Pattern-driven genomic features, including mutational signatures2, homologous recombination deficiency3, tumour mutational burden and tumour heterogeneity scores4, were associated with clinical outcomes, highlighting their potential utility as predictive biomarkers for clinical evaluation of treatments such as CDK4/6 and HER2 inhibitors, as well as adjuvant and neoadjuvant chemotherapy. These findings highlight the power of large-scale, clinically annotated whole-genome sequencing in advancing our understanding of how genomic alterations shape patient outcomes.
特别声明：本文转载仅仅是出于传播信息的需要，使用人工智能辅助研究的出版科学家，该谐振架构将有效泵浦功率提升了近十倍，文导闻科比先前演示的读新性能提升了一个数量级。获得的学网引用量是4.84倍，同源重组缺陷状态、研究者揭示了科学家对人工智能工具的加速采纳及其带来的持续职业优势，未被成功导入线粒体的Mge1进入细胞核，
由于后续交流互动的减少，大规模临床注释的全基因组测序能够有力推动理解基因组变异如何影响患者预后，通过光场循环利用同时提升了泵效率（转换率达95%）和泵浦功率利用率。科学家之间的学术互动减少了22%。
▲ Abstract：
Here we report an extreme barocaloric effect in NH4SCN aqueous solutions enabled by pressure-tuned dissolution and precipitation. This mechanism delivers an exceptionally large cooling capacity and markedly enhanced cooling efficiency. We obtain an in situ temperature drop of 26.8?K in the solution at room temperature, surpassing all known caloric materials. A Carnot-like cycle is designed to deliver 67?J?g?1 cooling capacity per cycle with a second-law efficiency of 77%, benefiting from the extremely large temperature drops and direct heat transfer due to the self-circulating aqueous solution. Beyond the phase-transition scenario, this dissolution-based approach that combines the merits of current leading technologies emerges as a promising sustainable refrigeration solution.
生物学Biology
An ancient recombination desert is a speciation supergene in placental mammals
一个古老的重组基因沙漠是胎盘哺乳动物中的一个物种形成超基因
▲ 作者：Nicole M. Foley, Richard G. Rasulis et al.
▲链接：
https://www.nature.com/articles/s41586-025-09740-2
▲摘要：
通过深度学习技术，
相比之下，请与我们接洽。
▲ Abstract：
化学Chemistry
Extreme barocaloric effect at dissolution
极端溶解压卡效应
▲ 作者：Kun Zhang, Yifang Liu et al.
▲链接：
https://www.nature.com/articles/s41586-025-10013-1
▲摘要：
研究者报道了基于硫氰酸铵水溶液在压力调控溶解与结晶过程中实现的极端压热效应。须保留本网站注明的“来源”，包含4130万篇研究论文且横跨不同人工智能时代的数据集，这凸显了个人学术晋升与集体科学进步之间的张力。8099期
材料科学Material Sciences
Low-power integrated optical amplification through second-harmonic resonance
通过二次谐波共振实现低功耗集成光放大
▲ 作者：Devin J. Dean, Taewon Park et al.
▲链接：
https://www.nature.com/articles/s41586-025-09959-z
▲摘要：
研究者展示了一种基于薄膜铌酸锂平台的集成光参量放大器，肿瘤突变负荷及肿瘤异质性评分——均与临床预后显著相关，这为理解肿瘤发生的早期机制提供了线索。也是必要条件，在不牺牲带宽的前提下，在演化中高度保守的大型连锁重组基因沙漠。并自负版权等法律责任；作者如果不希望被转载或者联系转载稿费等事宜，这一过程由Mge1与转录因子Pdr3在DNA调控元件上的直接相互作用介导。而非开拓新方向，因此，且平均提早1.37年成为研究项目负责人。但同时也伴随着科学研究探索的集体性收窄。人工智能工具似乎更倾向于自动化既有领域，
这一超基因的功能基础具有多重性，并不意味着代表本网站观点或证实其内容的真实性；如其他媒体、该X连锁重组沙漠是古老且反复出现的基因流动屏障，同时缩小了科学研究的探索
▲ 作者：Qianyue Hao, Fengli Xu, Yong Li & James Evans
▲链接：
https://www.nature.com/articles/s41586-025-09922-y
▲摘要：
通过一个涵盖自然科学领域、表明靶向序列不仅参与线粒体蛋白质输入，其区域富集了影响性染色体沉默与繁殖性状的相关基因。
▲ Abstract：
Using a dataset of 41.3 million research papers across the natural sciences and covering distinct eras of AI, here we show an accelerated adoption of AI tools among scientists and consistent professional advantages associated with AI usage, but a collective narrowing of scientific focus. Scientists who engage in AI-augmented research publish 3.02 times more papers, receive 4.84 times more citations and become research project leaders 1.37 years earlier than those who do not. By contrast, AI adoption shrinks the collective volume of scientific topics studied by 4.63% and decreases scientists’ engagement with one another by 22%. By consequence, adoption of AI in science presents what seems to be a paradox: an expansion of individual scientists’ impact but a contraction in collective science’s reach, as AI-augmented work moves collectively towards areas richest in data. With reduced follow-on engagement, AI tools seem to automate established fields rather than explore new ones, highlighting a tension between personal advancement and collective scientific progress.
医学Medicine
Whole-genome landscapes of 1,364 breast cancers
对1364例乳腺癌样本的全基因组图谱分析
▲ 作者：Ryul Kim, Jonghan Yu et al.
▲链接：
https://www.nature.com/articles/s41586-025-09812-3
▲摘要：
研究者通过对1364例具有临床注释的乳腺癌样本进行全基因组测序分析（多数样本同时具备转录组数据），融合了当前主流技术的优势，实验在室温溶液中实现了26.8K的原位温降，
相较于传统的单通式结构，这一突破相变范式的溶解基制冷方法，他们鉴定出一个占据X染色体30%长度、却收缩了科学整体的探索范围——因为人工智能辅助的研究集体性地转向了数据最密集的领域。这种低功耗架构为实现下一代量子与经典光子学系统中的实用化片上光参量放大器提供了可行路径。
在线粒体应激状态下，
▲ Abstract：
Here we reveal that the conserved mitochondrial Hsp70 co-chaperone, Mge1, acts as a stress messenger in budding yeast. During mitochondrial stress, unimported Mge1 entered the nucleus and triggered the transcription of mitoCPR target genes. This was mediated by the interaction of Mge1 with the transcription factor Pdr3 on DNA regulatory elements. The mitochondrial targeting sequence of Mge1 was both sufficient and essential for mitoCPR induction, demonstrating that in addition to their roles in mitochondrial protein import, targeting sequences can also function as signalling molecules. As protein import defects are a common consequence of various types of mitochondrial damage, these findings suggest a novel function for the targeting sequence of Mge1 as an indicator of mitochondrial health.
人工智能Artificial Intellligence
Artificial intelligence tools expand scientists’ impact but contract science’s focus
人工智能工具拓展了科学家的影响力， 编译|李言 Nature, 29 January 2026, Volume 649 Issue 8099 《自然》2026年1月29日，可用于评估CDK4/6抑制剂、并揭示了基因组特征的临床意义。它可能成为解析哺乳动物系统发育中复杂亲缘关系的可靠标记。该器件在输入功率低于200毫瓦的条件下实现了超过17分贝的增益，鉴定了新的驱动基因、人工智能的普及使科学界研究的主题总量缩减了4.63%， 这些发现表明，高频基因融合、 研究者采用二次谐波谐振设计， 实验证明，超越所有已知的热效应材料。有望成为可持续发展的新型制冷解决方案。其论文发表量是未使用者的3.02倍，研究设计的类卡诺循环每周期可提供67J/g的制冷量，基因组不稳定性在肿瘤确诊前数十年即已出现，推断了重组景观的演化历程。这些发现提示Mge1的靶向序列可能具有指示线粒体健康状况的新功能。为乳腺癌精准诊疗体系的构建提供关键数据支撑。 基于94个物种的重组感知系统基因组学分析表明，结构性变异与拷贝数变异。研究扩展了致癌性变异的类型谱系， 得益于溶液自循环带来的极大温降与直接传热优势，凸显其作为预测性生物标志物的潜力，HER2抑制剂以及辅助与新辅助化疗等治疗方案的临床效果。保守的线粒体Hsp70辅助伴侣蛋白Mge1可作为应激信号分子发挥作用。由于该位点支撑着跨目级谱系的生殖隔离，研究者对22种高分化胎盘哺乳动物的基因组比对数据进行分析，该器件在110纳米带宽范围内展现出平坦的接近量子极限的低噪声特性。激活线粒体蛋白质应激反应（mitoCPR）靶基因的转录。 模式驱动的基因组特征——包括突变特征、 Mge1的线粒体靶向序列既是诱导mitoCPR的充分条件， ▲ Abstract： Here we applied deep learning methods to genome alignments from 22 divergent placental mammal species to infer the evolution of the recombination landscape. We identified a large and evolutionarily conserved X-linked recombination desert constituting 30% of the chromosome. Recombination-aware phylogenomic analyses from 94 species revealed that the X-linked recombination desert is an ancient and recurrent barrier to gene flow and retains the species history when introgression dominates genome-wide ancestry. The functional basis for this supergene is manifold, enriched with genes that influence sex chromosome silencing and reproduction traits. Because the locus underpins reproductive isolation across ordinal lineages, it may represent a reliable marker for resolving challenging relationships across the mammalian phylogeny. A direct role for a mitochondrial targeting sequence in signalling stress 线粒体靶向序列在应激信号传导中的直接作用 ▲ 作者：Zixuan Yuan, Megan Balzarini et al. ▲链接： https://www.nature.com/articles/s41586-025-09834-x ▲摘要： 研究者揭示了在芽殖酵母中，系统刻画了其基因组全景图谱， 《自然》（20260129出版）一周论文导读